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KMID : 0352720000240030134
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Journal of Ginseng Research
2000 Volume.24 No. 3 p.134 ~ p.137
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Ginsenoside Rb1 Reduces Spontaneous Bursting Activity in Thalamocortical Slices of the Rat
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Chang Joong Lee/Sung Chil Yang
Sang Hun Lee/Jin Kyu Park/Min Whan Jung/Chang Joong Lee
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Abstract
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Spontaneous bursting activity was studied in rat thalamocortical slices using extracellular field potential recording to test the potential utilization of ginsenoside Rb1 in controlling overactivated neural systems. In order to induce bursting activity, slices were perfused with Mg2+/-free artificial cerebrospinal fluid (ACSF). Two major types of spontaneous bursting activity, simple thalamocortical burst complexes (sTBCs) and complex thalamocortical burst complexes (cTBCs), were recorded in Mg2+/ -free ACSF. Ginsenoside Rb1 selectively suppressed cTBCs. Duration and occurrence rate of cTBCs were reduced by 87.3 ± 10.2% and 85.3 ± 14.7% in the presence of 90 μM ginsenoside Rb1 respectively, while amplitude and intraburst frequency were slightly changed by ginsenoside Rb1. In contrast, ginsenoside Rb1 was much less effective in reducing duration and occurrence rate of sTBCs. We also tested effects of ginsenoside Rb1 on bursting activity in the presence of a GABA A/ receptor antagonist, bicuculline methiodide (BMI). Ginsenoside Rb1 had no effect in suppressing BMI-induced bursting activities. These results suggest that ginsenoside Rbi may be useful in controlling seizure-like bursting activity under pathological conditions.
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KEYWORD
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Ginseng, Ginsenoside Rb1, Seizure, Thalamocortical Slice, Antiepileptic Activity,
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